Cognitive Health is Booming—And Cognizin® is Leading the Way
Consumers today are increasingly prioritizing cognitive wellness. From professionals seeking sharper focus to athletes optimizing mental endurance and aging populations supporting long-term brain function, the demand for science-backed nootropics is soaring.1
- The global brain health supplements market, valued at $6.29 billion in 2024, is projected to reach $11.55 billion by 2032, growing at an 8% CAGR.
- The U.S. market alone stood at $3.21 billion in 2023 and is expected to grow at 11.2% CAGR from 2024 to 2030 as demand for functional cognitive ingredients rises.2
At the same time, personalized nutrition and functional foods are reshaping the industry. Consumers expect more than just basic vitamins—they want clinically researched, multi-benefit ingredients that enhance focus, memory, and mental endurance while aligning with clean-label and sustainability trends.3,4
Why Branded Ingredients Matter
As competition grows, manufacturers and formulators must set their products apart with scientifically validated ingredients. Unlike generic ingredients, Cognizin® Citicoline is backed by extensive clinical research, making it a trusted choice for brands seeking performance-driven formulations.
Science-supported ingredients not only enhance efficacy but also strengthen consumer confidence. When an ingredient like Cognizin has been around for as long as it has, it gives the opportunity for continuous testing and retesting to ensure and support the function-specific claims made about the ingredient.
Cognizin is the only branded citicoline clinically studied in healthy adults and adolescents. With multiple U.S. and EU patents, it delivers benefits for focus, attention, memory, and mental processing speed. For formulators seeking a research-backed, high-efficacy ingredient, Cognizin provides a powerful solution and strategic advantage for next-generation cognitive health products.
Scientific Advantages of Cognizin®:
The Complete Cognitive Solution
In a market where cognitive support ingredients vary in quality and efficacy, Cognizin sets itself apart as a patented ingredient with extensive clinical research, providing essential brain nutrients for both immediate cognitive function and long-term brain health. Cognizin citicoline is among the most clinically researched brain health ingredients, giving it a unique edge against other ingredients used in the cognitive health space.
1 - Sherman, Asia. "The Evolution of Cognitive Health Supplements Market." NutraIngredients-USA, Jan. 15, 2025
2 - Grand View Research. “U.S. Brain Health Supplements Market Size... 2024-2030.”
3 - MarketsandMarkets. "Nutraceuticals & Dietary Supplements Industry Outlook." Dec. 2024
4 - Future Market Insights. "Rising Health Awareness... Forecast to Grow at 4.1% CAGR by 2033." Nov. 11, 2024
Cognitive Benefits for Real-World Applications
Cognizin citicoline has been tested in human studies, demonstrating its ability to support concentration, mental energy, and memory. It's been shown to help improve focus, attention, and reaction time. Research also highlights its role in reducing errors and improving accuracy. Consumers associate Cognizin with credibility that elevates finished products with a premium and gold standard ingredient.
Cognizin® Citicoline is ideal for cognitive products supporting cognitive performance and lasting brain health.
Curious about the science behind Cognizin, the gold-standard ingredient for cognitive health? Download our Scientific Research & Approved Claims sheet for a detailed look at its cognitive health advantages.
Dual-Action Brain Support: Performance + Protection
Cognizin citicoline supports cognitive health through multiple mechanisms of action. As a choline donor, it provides all the benefits of choline while also contributing to the production of phospholipids essential for brain cell function, structure, and communication—offering broader neuroprotective support.
- Phosphatidylcholine (PC) - Supports brain cell membrane integrity and neurotransmission.
- Phosphatidylethanolamine (PE) - Aids membrane fluidity for optimal neural communication.
- Phosphatidylserine (PS) - Plays a key role in neuroprotection and cognitive resilience.
Cognizin supports both acetylcholine production for neurotransmission and phospholipid synthesis for brain cell integrity, offering comprehensive cognitive support.
Advancing Brain Health Through Science
Cognizin isn't just a performance nootropic—it's backed by research on neuroprotection which implies benefits for long-term brain health. Studies indicate that citicoline helps combat oxidative stress and supports brain energy metabolism, two crucial factors for maintaining cognitive resilience over time.
Want to explore Cognizin's role in antioxidant defense, cellular health, and oxidative stress management? Download our brochure for the latest scientific insights.
Patented Cognitive Innovation
Cognizin holds multiple U.S. and EU patents that protect its proprietary production process and advanced formulation. These patents reinforce its superior quality and targeted efficacy, distinguishing it from generic choline and citicoline sources.
US Patents: 12115181, 11583546, 11738037, 10905705
EU Patents: EP2914270B1, EP3137067B1
Cognizin's fermentation process also ensures exceptional purity, stability, and solubility, making it ideal for dietary supplements, functional beverages, and cutting-edge nootropic formulations.
The Cognizin® Timeline: A Legacy of Innovation
From its scientific discovery to industry leadership, Cognizin has continually evolved to meet the demands of sports nutrition, eSports, and functional wellness. Today, it remains the go-to ingredient for brands seeking evidence-based cognitive support.
Born from years of research and innovation at Kyowa Hakko Bio, a pioneer in the industry, Cognizin has been studied for decades.
As the demand for science-driven nootropics rises, Cognizin continues to set new standards in innovation, efficacy, and real-world results.
Why Manufacturers and Formulators Choose Cognizin® Citicoline
With extensive scientific and clinical research backing Cognizin, manufacturers and formulators can confidently integrate it into a variety of products. Cognizin delivers exceptional quality, stability, and formulation versatility, making it a preferred cognitive health ingredient for functional foods, beverages, and dietary supplements.
Designed for convenience, Cognizin offers practical benefits that manufacturers and formulators love:
PURE
Contains no food additives, artificial flavors or preservatives
NEUTRAL IN TASTE
Neutral and slightly acidic taste compliments numerous product flavors
WATER-SOLUBLE
Easy to use in beverages and liquids
STABLE
Is stable in liquids and in high heat
GRAS
Self-affirmed GRAS status achieved in 2009 and is considered safe for food and beverage applications
VEGETARIAN
No animal origin material is used in Cognizin®
ALLERGEN-FREE
Considered allergen-free
KOSHER
Certified as Kosher ingredient
FERMENTATION
Produced by an innovative fermentation process
NON-GMO
Contains no food additives, artificial flavors or preservatives
Cognizin® Product Applications* include:
- Dietary supplements
- Beverages & beverage bases
- Breakfast cereals
- Chewing gum
- Dairy product analogs
- Frozen dairy desserts
- Hard & soft candies
- Milk & milk products
- Processed fruits & fruit juices
- *United States Market
Beyond an Ingredient: The Kyowa Hakko Difference
Cognizin is distributed globally by Kyowa Hakko Bio Co. Ltd., a leader in fermentation technology, ingredient innovation, and scientific research. With over 75 years of expertise in product development, Kyowa Hakko supplies high-quality, branded ingredients for dietary supplements, functional foods, and beverages.
With an unwavering dedication to purity, safety, and efficacy, we ensure Cognizin meets the highest standards for scientific validation, stability, and performance.
A Commitment to Sustainability
Kyowa Hakko integrates sustainability at every stage of production, aligning with consumer expectations for ethical, eco-conscious products. We minimize our impact through responsible sourcing, energy-efficient manufacturing, and environmental conservation while maintaining the highest quality standards. By prioritizing eco-friendly initiatives, Kyowa Hakko ensures Cognizin is produced responsibly.
Strategic Partnerships That Drive Brand Success
When you partner with Kyowa Hakko, you gain more than just premium ingredients—you gain a strategic ally in product success. Our team provides regulatory guidance, technical expertise, and marketing resources to help brands navigate formulation challenges, compliance requirements, and consumer engagement.
From labeling claims and formulation suggestions to sales and retail training, we offer end-to-end support that ensures your product meets the highest standards while standing out in a competitive market.
Use our branded ingredients toolkit to enhance your brand and customer experience.
Our comprehensive support includes:
- Regulatory & labeling guidance to ensure compliance
- Technical expertise to optimize formulation & stability
- Sales and retail training to educate key stakeholders
- Research-backed consumer education for market credibility
- Social media support to drive awareness
- Customizable marketing materials for effective brand storytelling
- eCommerce and retail integration for seamless distribution
We don't just supply ingredients—we help you bring them to market successfully.
Ready to Elevate Your Formula?
Tap into Kyowa Hakko's expertise to stay ahead in cognitive health innovation. Leverage Cognizin® Citicoline's clinically researched benefits, regulatory support, and customizable marketing solutions to create stand-out formulations. Contact us today to get started!
Unlock the Potential of Cognizin® for Your Market